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UNC0646

品牌
J&K
CAS
1320288-17-2
货号
1834957
规格纯度
98%, 是G9a选择性抑制剂, IC50为6 nM
参考价格
707 *本价格含增值税费
促销
服务
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数量
-+
产品名称:
1320288-17-2
UNC0646
产品介绍:

基本信息

分子式C36H59N7O2
分子量621.90
存储条件Freezer -20℃

产品描述

UNC0646 is a potent and selective G9a inhibitor with IC50 of 6 nM. IC50 value: 6 nM [1] Target: G9a UNC0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50 values are 6 nM and 15 nM for G9a and GLP, respectively). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50 = 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50 = 4.7 μM in MCF7 cells). UNC0646 is selective for G9a/GLP over a range of other protein lysine methyltransferases and protein arginine methyltransferases.

参考文献

[1]. Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

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