Transcrocetin (trans-Crocetin), extracted from saffron (Crocus sativus L.), acts as anNMDA receptorantagonist with high affinity^[1]. Transcrocetin (trans-Crocetin) is capable of crossing the blood-brain barrier and reach the central nervous system (CNS)^[2].

Transcrocetin (trans-Crocetin), a saffron metabolite originating from the crocin apocarotenoids, has been shown to exert strong NMDA receptor affinity and is thought to be responsible for the CNS activity of saffron.To ensure unchanged viability of Caco-2 cells throughout the transport experiments, cellular mitochondrial dehydrogenase activity of Caco-2 cells is measured by MTT assay after a 24 h incubation period with the test compounds: Hydroalcoholic saffron extract saffron extract (SE, 0.5-1 mg/mL) and crocin-1 (250-1000 μM) reveal no negative significant changes in cellular viability. Transcrocetin at 10 μM level does not change viability while higher concentrations (40-160 μM) reduces significantly cellular viability^[1].

328.40

Solid

C₂₀H₂₄O₄

27876-94-4

藏红花酸；西红花酸；番红花酸

• Terpenoids
• Diterpenoids

• Plants
• Lridaceae
• Crocus sativusL.

Room temperature in continental US; may vary elsewhere.

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DMSO : 1 mg/mL(3.05 mM;Need ultrasonic and warming)

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