MOMIPP，一种巨胞饮作用的诱导剂，是一种PIKfyve抑制剂。MOMIPP 可穿过血脑屏障 (BBB)。
| 生物活性 | MOMIPP, a macropinocytosis inducer, is aPIKfyveinhibitor. MOMIPP penetrates the blood-brain barrier (BBB)[1][2]. |
体外研究
(In Vitro) | MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations[1].
In U373 and Hs683 cell lines, 3 μM for MOMIPP induces cell vacuolization[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL[2].
Western Blot Analysis[2] | Cell Line: | U251 cells | | Concentration: | 10 μM | | Incubation Time: | 4 h or 24 h | | Result: | Activated the JNK stress kinase pathway. |
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体内研究
(In Vivo) | MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts[2].
| Animal Model: | Athymic CrTac:NCR-Foxn1mice (female, 7-8 weeks)[2] | | Dosage: | 80 mg/kg | | Administration: | i.p.; once daily; for 15 consecutive days | | Result: | Suppressed progression of intracerebral glioblastoma xenografts. |
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | | Powder | -20°C | 3 years | | In solvent | -80°C | 6 months | | -20°C | 1 month |
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| 溶解性数据 | In Vitro: DMSO : 31.25 mg/mL(106.90 mM;ultrasonic and warming and heat to 60℃) 配制储备液 | 1 mM | 3.4208 mL | 17.1040 mL | 34.2079 mL | | 5 mM | 0.6842 mL | 3.4208 mL | 6.8416 mL | | 10 mM | 0.3421 mL | 1.7104 mL | 3.4208 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。 |
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