| CAS NO: | 6610-25-9 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 326.45 |
| Cas No. | 6610-25-9 |
| Formula | C20H31NaO2- |
| Solubility | ≤1.5mg/ml in ethanol |
| Chemical Name | A name could not be generated for this structure. |
| Canonical SMILES | CCCCC/C=C\C/C=C\C/C=C\C/C=C\CCCC([O-])=O.[Na] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Arachidonic acid (sodium salt) is an essential fatty acid [1].
Arachidonic acid is an integral constituent of cell membrane, rendering it with fluidity and flexibility, so necessary for the function of all cells, especially in nervous system, skeletal muscle, and immune system. In its free form, arachidonic acid modulates the function of ion channels, several receptors and enzymes, via activation as well as inhibition [1].
Arachidonic acid at the concentration of 5 mM, irreversibly killed 1-, 3-, 4-, 5-, and 6-week-oldSchistosoma mansoni (S. mansoni) and 9-, 10-, and 12-week-oldSchistosoma haematobium (S. haematobium) worms within 3 to 4 h [2]. In PC-3 prostate cancer cells, arachidonic acid (0, 0.1, 0.5, 5 or 10 μg/ml) induced expression ofcox-2,cPLA2 andc-fos message in a dose-dependent manner. Furthermore, proliferation of human prostate cells was significantly increased 48 h after arachidonic acid addition [3].
In BALB/c or C57BL/6 mice, a single oral dose of arachidonic acid (500 or 1000 mg/kg forS. mansoni, 1000 mg/kg forS. haematobium) led to a significant reduction of 31.2 to 39.3% in theS. mansoni and 57% in theS. haematobium total worm burden [2].
References:
[1]. Tallima H, El Ridi R. Arachidonic acid: Physiological roles and potential health benefits - A review. Journal of Advanced Research, 2017, 11: 33-41.
[2]. El Ridi R, Aboueldahab M, Tallima H, et al. In vitro and in vivo activities of arachidonic acid against Schistosoma mansoni and Schistosoma haematobium. Antimicrobial Agents and Chemotherapy, 2010, 54(8): 3383-3389.
[3]. Hughes-Fulford M, Tjandrawinata R R, Li C F, et al. Arachidonic acid, an omega-6 fatty acid, induces cytoplasmic phospholipase A2 in prostate carcinoma cells. Carcinogenesis, 2005, 26(9): 1520-1526.
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