Cedrol

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Cedrol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

77-53-2

包装与价格：

包装	价格(元)
Free Sample (0.1-0.5mg)	电议
100mg	电议
200mg	电议
500mg	电议

产品介绍

Cedrol 是一种生物活性倍半萜，一种有效的细胞色素 P-450(CYP) 酶竞争性抑制剂。 Cedrol 抑制 CYP2B6 介导的安非他酮羟化酶和 CYP3A4 介导的咪达唑仑羟基化，Ki 分别为 0.9 μM 和 3.4 μM。 Cedrol 对 CYP2C8，CYP2C9 和 CYP2C19 酶也具有弱抑制作用。Cedrol 存在于雪松精油中，具有抗脓毒，抗炎，抗痉挛，滋补，收敛，利尿，镇静，杀虫和抗真菌活性。

Cas No.	77-53-2
别名	柏木脑,(+)-Cedrol; α-Cedrol
Canonical SMILES	O[C@]1(C)CC[C@]23[C@H](C)CC[C@@]2([H])C(C)(C)[C@@]1([H])C3
分子式	C₁₅H₂₆O
分子量	222.37
溶解度	Chloroform: Slightly Soluble,Methanol: Heated
储存条件	4°C, protect from light
General tips	For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition	Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request
产品描述	Cedrol is a bioactive sesquiterpene, a potent competitive inhibitor of cytochrome P-450 (CYP) enzymes. Cedrol inhibits CYP2B6-mediated bupropion hydroxylase and CYP3A4-mediated midazolam hydroxylation with Ki of 0.9 μM and 3.4 μM, respectively. Cedrol also has weak inhibitory effect on CYP2C8, CYP2C9, and CYP2C19 enzymes[1]. Cedrol is found in cedar essential oil and poetesses anti-septic, anti-inflammatory, anti-spasmodic, tonic, astringent, diuretic, sedative, insecticidal, and anti-fungal activities[2]. [1]. Jeong HU, et al. Inhibitory effects of cedrol, β-cedrene, and thujopsene on cytochrome P450 enzyme activities in human liver microsomes. J Toxicol Environ Health A. 2014;77(22-24):1522-32. [2]. Jin MH, et al. Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner. Ann Dermatol. 2012 Feb;24(1):16-21