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Leucinostatin A
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Leucinostatin A图片
CAS NO:76600-38-9
包装与价格：
包装价格(元)
500μg电议
2.5mg电议

产品介绍
Leucinostatin A (Antibiotic P168) 是一种九肽，对白色念珠菌和新型隐球菌具有显着的活性。
Cas No.76600-38-9
别名白灰制菌素A,Antibiotic P168
Canonical SMILESCC(C)C[C@H](NC([C@H](CC(C)C)NC(C(C)(C)NC([C@H]([C@@H](C(C)C)O)NC([C@@H](NC([C@H]1N(C(/C=C/[C@@H](C)CC)=O)C[C@@H](C)C1)=O)C[C@H](C)C[C@H](O)CC(CC)=O)=O)=O)=O)=O)C(NC(C)(C)C(NC(C)(C)C(NCCC(N[C@@H](C)CN(C)C)=O)=O)=O)=O
分子式C62H111N11O13
分子量1218.6
溶解度DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Leucinostatin A is a fungal metabolite originally isolated from P. lilacinus with diverse biological activities. It is active against P. oryzae, B. cinera, P. chrysogenum, X. oryzae, S. cerevisiae, and C. albicans fungi and B. subtilis, S. aureus, S. lutea, and M. phlei bacteria in a disc assay. Leucinostatin A (0.1-1 μg/ml) reduces T cell activation induced by phorbol 12-myristate 13-acetate or an anti-CD3 antibody in a concentration-dependent manner. It inhibits proliferation of DU145 prostate cancer cells co-cultured with PrSC stromal cells in vitro (IC50 = 0.045 μg/ml).