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PHPS1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
PHPS1图片
CAS NO:314291-83-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
PHPS1 是一种有效的选择性 Shp2 抑制剂，对 Shp2、Shp2-R362K、Shp1、PTP1B 和 PTP1B-Q 的 Kis 分别为 0.73、5.8、10.7、5.8 和 0.47 μM。
Cas No.314291-83-3
别名PTP Inhibitor V
化学名4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid
Canonical SMILESO=C1N(C2=CC=CC=C2)N=C(C3=CC=C([N+]([O-])=O)C=C3)/C1=N\NC4=CC=C(S(O)(=O)=O)C=C4
分子式C21H15N5O6S
分子量465.4
溶解度5mg/mL in DMSO, or in DMF
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 μ Ki = 0.73 &#181M). It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 &#181M, respectively). PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.

Reference:
[1]. Hellmuth, K., Grosskopf, S., Lum, C.T., et al. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proceedings of the National Academy of Sciences of the United States of America 105(20), 7275-7280 (2008).