CAS NO: | 2672568-86-2 |
包装 | 价格(元) |
500 µg | 电议 |
1mg | 电议 |
5mg | 电议 |
Cas No. | 2672568-86-2 |
Canonical SMILES | [2H]C1=CC([2H])=C(N)C(C(C([2H])([C@@H](C(O)=O)N)[2H])=O)=C1 |
分子式 | C10H8D4N2O3 |
分子量 | 212.2 |
溶解度 | DMF: 0.5mg/mL,DMSO: 1mg/mL,Ethanol: 2mg/mL |
储存条件 | -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | L-Kynurenine-d4is intended for use as an internal standard for the quantification of kynurenine by GC- or LC-MS. L-Kynurenine is an active metabolite of tryptophan .1It is formed from tryptophanviatryptophan 2,3-dioxygenase (TDO) or indoleamine 2,3-dioxygenase (IDO). L-Kynurenine binds to the aryl hydrocarbon receptor (AhR; Kd =~4 µM) and increases the activity of ethoxyresorufin-O-deethylase (EROD) in H-4-II-E rat hepatoma cells (EC50= 12.3 µM).2It decreases intracellular concentrations of NAD+in, and increases lactate dehydrogenase (LDH) activity in the supernatant of, primary human astrocytes and neurons in a concentration-dependent manner.3L-Kynurenine in combination with IFN-γ reduces lung injury induced byA. fumigatusinfection in thep47phox-/-mouse model of chronic granulomatous disease.4 1.Stone, T.W., Forrest, C.M., and Darlington, L.G.Kynurenine pathway inhibition as a therapeutic strategy for neuroprotectionFEBS J.279(8)1386-1397(2012) 2.Opitz, C.A., Litzenburger, U.M., Sahm, F., et al.An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptorNature478(7368)197-203(2011) 3.Braidy, N., Grant, R., Brew, B.J., et al.Effects of kynurenine pathway metabolites on intracellular NAD+ synthesis and cell death in human primary astrocytes and neuronsInt. J. Tryptophan Res.261-69(2009) 4.Romani, L., Fallarino, F., De Luca, A., et al.Defective tryptophan catabolism underlies inflammation in mouse chronic granulomatous diseaseNature451(7175)211-215(2008) |