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(Rac)-CFT7455
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(Rac)-CFT7455图片
CAS NO:2504233-68-3
包装与价格：
包装价格(元)
5mg电议
10mg电议

产品介绍
(Rac)-CFT7455 是一种 Ikaros/Aiolos 降解剂，通过泛素蛋白酶体途径起作用，对 NCIH929.1 细胞的 GI50 为 0.05 nM。(Rac)-CFT7455 是具有抗癌活性的 CFT7455 的外消旋异构体。
Cas No.2504233-68-3
分子式C28H27N3O4
分子量469.53
溶解度DMSO : 62.5 mg/mL (133.11 mM; ultrasonic and warming and heat to 60°C)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(Rac)-CFT7455 is a zinc finger transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) degrader, acting via the ubiquitin proteasome pathway, with a GI50 of 0.05 nM for NCIH929.1 cells. (Rac)-CFT7455 is the racemic isomer of CFT7455 which is a IKZF1/IKZF3 degrader with anticancer activity[1][2].

[1]. David Proia et al. Advantageous therapies for disorders mediated by ikaros or aiolos. WO2022032132A1 (compound 5)
[2]. James A. Henderson, et al. Abstract LB007: CFT7455: A novel, IKZF1/3 degrader that demonstrates potent tumor regression in IMiD-resistant multiple myeloma (MM) xenograft models. Cancer Res (2021) 81 (13_Supplement): LB007.