Mcl1-IN-8 (Comp8) 是 Mcl-1-PUMA 的抑制剂，Ki 值为0.3 μM。Mcl1-IN-8 (Comp8) 在下调PUMA依赖的凋亡的同时还能抑制Mcl-1介导的癌细胞抗凋亡作用。
货号:ajcx15406
CAS:678158-55-9
分子式:C22H23N3O2S
分子量：393.5
溶解度:DMSO: 50 mg/mL (127.06 mM)
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Mcl1-IN-8 (Comp8) is a Mcl-1-PUMA interface inhibitor, with a Ki of 0.3 μM. Mcl1-IN-8 (Comp8) exhibits dual activity on reduce PUMA-dependent apoptosis while deactivating Mcl-1-mediated anti-apoptosis in cancer cells[1].

[1]. Liu J, et al. Targeting the apoptotic Mcl-1-PUMA interface with a dual-acting compound. Oncotarget. 2017 Apr 20;8(33):54236-54242.