| 包装: | 500ug |
| 规格: | 98% |
| 市场价: | 3674元 |
| 分子量: | 3009.36 |
Background:
Amylin (AMY3) antagonist (IC50 = 0.3 μM). Protects neuronal cells from Aβ(1-42)-induced cytotoxicity in vitro. Brain penetrant. Improves spatial memory and reduces Aβ plaque number and total area in a mouse Alzheimer's disease model.
Soudy et al (2016) Cyclic AC253, a novel amylin receptor antagonist, improves cognitive deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. (N Y) 3 44 PMID:29067318 |Mietlicki-Baase (2018) Amylin in Alzheimer's disease: Pathological peptide or potential treatment• Neuropharmacology 136 287 PMID:29233636
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