| 包装: | 5mg |
| 规格: | 98% |
| 市场价: | 3586元 |
| 分子量: | 1106.25 |
Background:
c-MET degrader. Comprises MET inhibitor foretinib (GSK 1363089; ) joined by a linker to a von Hippel-Lindau (VHL) recruiting ligand. Degrades c-MET within 6 hours in vitro. Inhibits agonist-driven AKT phosphorylation and GTL16 cell proliferation (IC50 = 66.7 nM). Also degrades exon-14-deleted c-MET in Hs746T cells.
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