Guaiacol是一种从愈创木树脂分离的酚类化合物，抑制LPS刺激的COX-2表达和NF-κB激活。具有抗炎活性。
CAS：90-05-1
分子式：C7H8O2
分子量：124.14
纯度：98%
存储：Store at -20°C

Background:

Guaiacol, a phenolic compound isolated from Guaiac resin, inhibits LPS-stimulated COX-2 expression and NF-κB activation[1]. Anti-inflammatory activity[1].

Guaiacol inhibits LPS-stimulated nuclear factor kappa B (NF-κB) activation and cyclooxygenase (COX)-2 gene expression in cells of the RAW 264.7 murine macrophage cell line. Phenolic compounds such as Phenol, Eugenol, Guaiacol and Vanillin inhibit sheep vesicular gland prostaglandin cyclooxygenase, as indicated by their 50% inhibition concentrations, which decline in the following order: Phenol (1600 μM) >Vanillin (>500 μM) >Guaiacol (72 μM) >Eugenol (12 μM)[1].

[1]. Murakami Y, et al. Re-evaluation of cyclooxygenase-2-inhibiting activity of vanillin and Guaiacol in macrophages stimulated with lipopolysaccharide. Anticancer Res. 2007 Mar-Apr;27(2):801-7.