Dilmapimod(SB-681323)是有效的p38MAPK抑制剂，能够有效抑制慢性阻塞性肺病引起的炎症。
CAS：444606-18-2
分子式：C23H19F3N4O3
分子量：456.42
纯度：98%
存储：Store at -20°C

Background:

Dilmapimod (SB-681323) is a potent p38 MAPK inhibitor that potentially suppresses inflammation in chronic obstructive pulmonary disease.

Dilmapimod (SB-681323) potently inhibits p38 MAPK signaling, measured by inhibition of sorbitol-induced pHSP27 expression[1].

[1]. Singh D, et al. A randomized, placebo-controlled study of the effects of the p38 MAPK inhibitor SB-681323 on blood biomarkers of inflammation in COPD patients. J Clin Pharmacol. 2010 Jan;50(1):94-100.