PD-217014 is a new GABA analogue that inhibits (3)H-gabapentin binding to alpha(2)delta subunit of voltage-gated calcium channels in a concentration-dependent manner (K(i) = 18 nmol/l). PD-217014 is a potent alpha(2)delta ligand and possesses visceral analgesic activity. Potential for the treatment of overactive bladder (OAB), irritable bowel syndrome (IBS) References: Ohashi K, Kawai M, Ninomiya N, Taylor C, Kurebayashi Y. Effect of a new alpha 2 delta ligand PD-217014 on visceral hypersensitivity induced by 2,4,6-trinitrobenzene sulfonic acid in rats. Pharmacology. 2008;81(2):144-50. Epub 2007 Nov 7. PubMed PMID: 17989503.

纯度：≥98%

CAS：444088-20-4