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Butylparaben
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Butylparaben图片
CAS NO:94-26-8
包装与价格:
包装价格(元)
500 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Butyl 4-hydroxybenzoate
尼泊金丁酯
对羟基苯甲酸丁酯
Butyl parahydroxybenzoate
产品介绍
Butylparaben是一种标准化的化学过敏原,可增加组胺释放和细胞介导的免疫。

产品描述

Butylparaben is a standardized chemical allergen, increasing histamine release, and cell-mediated immunity.

体外活性

After butylparaben treatment, vimentin filaments in Sertolicells are disrupted. Sertoli cell cytoskeleton responds to butylparaben by exhibiting a marked collapse in vimentin filaments distribution[1].

体内活性

Butylparaben induces collapse of Sertoli cell vimentin filaments in vivo[1]. Exposure of a postweaning mammal to butylparaben had an adverse effect on the secretion of testosterone and in the functions of the male reproductive system[2].

细胞实验

Mixed cultures of Sertoli and spermatogenic cells are prepared from three-week-old SD rats. Single cells are obtained by gravity sedimentation and use of 50% trypsin-EDTA. Cells are finally suspended at a concentration of 1 × 108cell/ml and maintained for 24 h in Dulbecco’s modified Eagle medium supplemented with 100 U/ml penicillin, 100 μg/ml streptomycin, and 10% fetal bovineserum. Thereafter, cells are maintained in serum-freemedium, which is changed every 24 h. At 72 h, spermatogenic cells are removed by treatment with hypotonic Tris buffer (20 mMTris–HCl, pH 7.4) for 5 min. The Sertoli cell-enriched cultures obtained are then maintained in serum-free medium for 24 h before being reseeded onto chamber slides. The samples are cultured for a further 5 days. Subsequently, they are exposed to 0, 1, 100 and 1000 nmol/ml butylparaben for 6 and 24 h. Some slides are stained with 0.5% toluidine blue for light microscopic observations, whereas the rest are used for vimentin immuno-histochemical analysis. (Only for Reference)

Cas No.

94-26-8

分子式

C11H14O3

分子量

194.23

别名

Butyl 4-hydroxybenzoate;尼泊金丁酯;对羟基苯甲酸丁酯;Butyl parahydroxybenzoate;Butylparaben

储存和溶解度

H2O:35 mg/mL (180.2 mM)
DMSO:36 mg/mL (185.3 mM)
Ethanol:36 mg/mL (185.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years