4-oxo-27-TBDMS Withaferin A is a derivative of the steroidal lactone withaferin A that has anticancer activity.1 It is cytotoxic to A2780 ovarian cancer cells (IC50 = 17 μM) but not to carboplatin-resistant A2780 (A2780/CP70) cells (IC50 = >100 μM). It is selective for A2780 cells over non-cancerous ARPE19 cells (IC50 = 1,660 μM). 4-oxo-27-TBDMS Withaferin A induces DNA fragmentation in A2780 cells.

1214886-31-3

C34H50O6Si

582.84

4-oxo-27-TBDMS Withaferin A

DMSO:5 mg/mL
DMF:5 mg/mL
DMSO:PBS (pH 7.2) (1:1):0.5 mg/mL
Powder: -20°C for 3 years
In solvent: -80°C for 2 years