BR-1 是 PRL-3 抑制剂，IC50=0.9 μM。它在细胞检测中显示降低侵袭性。

BR-1 is a phosphatase of regenerating liver 3 (PRL-3) inhibitor which blocks the migration and invasion of metastatic cancer cells.

PRL-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of DiFMUP by PRL-3 and strongly suppressed the activity of PRL-3 phosphatase in PRL-3 overexpressing DLD-1 colon tumor cells [DLD-1 (PRL-3)]. Also, PRL-3 inhibitor dose-dependently blocked the migration of DLD-1 (PRL-3) cells, however, it did not inhibit the proliferation of DLD-1(PRL-3) cells, suggesting that PRL-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity

893449-38-2

C17H11Br2NO2S2

485.21

PRL-3 Inhibitor;BR-1

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years