BobCAT339 是一种基于胞嘧啶的选择性TET酶抑制剂，抑制TET1和TET2的IC50值分别为 33 和 73 μM。它可作为靶向 DNA 甲基化和基因转录新疗法的起点，用于表观遗传学领域研究。
产品描述
Bobcat339 is a novel cytosine-based TET enzyme inhibitor (IC50s: 33/73 uM for TET1/2), but not DNMT3a, does not inhibit the DNA methyltransferase DNMT3a.
体外活性
HT-22 cells were treated with 10 μM Bobcat339 in 1% DMSO for 24 hrs and lysed. Cells treated with Bobcat339 had significantly reduced global 5hmC levels as compared to vehicle control.
Cas No.
2280037-51-4
分子式
C16H12ClN3O
分子量
297.74
别名
Bobcat339 hydrochloride;盐酸Bobcat339
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
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