Torezolid是一种新型恶唑烷酮,可与核糖体50S亚基的23S核糖体RNA结合抑制细菌的蛋白质合成。
产品描述
Tedizolid is an Oxazolidinone Antibacterial. The mechanism of action of tedizolid is as a Breast Cancer Resistance Protein Inhibitor.
体外活性
Tedizolid (0.25 μg/mL) inhibits all 28 clinical isolates of PRSP which is 4-fold more potent than linezolid against PRSP[1].
体内活性
The tedizolid phosphate at a minimum total daily dose of 10 mg/kg achieved a 100% survival rate for mice infected with PSSP type III. Lungs of infected mice treated with tedizolid phosphate show less severe inflammation and edema, as indicated by the mean scores for inflammation and edema[1].
Cas No.
856866-72-3
分子式
C17H15FN6O3
分子量
370.34
别名
DA-7157;泰地唑利;Torezolid;特地唑胺;TR 700
储存和溶解度
DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years