Fumaric acid 与烟酸酶缺乏症相关，是癌症相关的内源性代谢物。

Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Fumaric acid has recently been identified as an oncometabolite or an endogenous, cancer-causing metabolite. High levels of this organic acid can be found in tumors or biofluids surrounding tumors. Its oncogenic action appears due to its ability to inhibit prolyl hydroxylase-containing enzymes.

110-17-8

C4H4O4

116.1

2-Butenedioic acid;Trans-Butenedioic acid;反丁烯二酸;Fumarate;富马酸;Donitic acid;Lichenic acid;Allomaleic acid

DMSO:21 mg/mL(180.9 mM)
Chloroform, Dichloromethane, Ethyl Acetate, Acetone:Soluble
Powder: -20°C for 3 years
In solvent: -80°C for 2 years