Safranal 是藏红花的主要成分，具有口服活性，是这种香料的独特香气来源。它具有神经保护和抗炎作用，对帕金森氏病具有潜在的研究价值。

Safranal is the special volatile aroma compound of saffron.Safranal has neuroprotective and anti-inflammatory effects and has the potential for Parkinson’s disease research.

At first, the potential toxic effect of safranal on OLN-93 viability was evaluated. Also, the cells were pretreated with safranal (0.1, 1, 10, 50, 100 and 200 μM) for 2 h and then subjected to glutamic acid (16 mM) or quinolinic acid (8 mM) toxicity for 24 h, in which the same treatments were applied. Results: Safranal at concentration ranges of 1-800 μM had no toxic effect on cell viability (p>0.05). Treatment with safranal significantly increased cell viability following glutamic acid or quinolinic acid insults at concentrations higher than 1 μM (p<0.01). The cytoprotective potential of safranal was also accompanied by decreased ROS accumulation (p<0.001) and malondialdehyde level (p<0.001) following glutamic acid or quinolinic acid insults. The data suggests that safranal exhibits oligoprotection potential by means of inhibiting oxidative stress parameters.

Safranal (200-500 mg/kg; PO; for 7 days) causes a slight restoration of colon length and percentage of weight loss, and the DAI score is significantly low[2].

116-26-7

C10H14O

150.22

藏红花;2,3-二氢-2,2,6-三甲基苯甲醛;藏红花醛

DMSO:100 mg/mL (665.69 mM),Need ultrasonic
Ethanol:100 mg/mL (665.69 mM）,Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years