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位置:首页 > 品牌 > 百灵威科技 > 2-氨乙基 (R)-2,3-二(2-油酰氧)丙基磷酸氢酯

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine

1,2-二油酰-sn-甘油-3-磷酰乙醇胺

品牌
J&K
CAS
4004-05-1
货号
592416
包装型号
规格纯度
98%
参考价格
333 *本价格含增值税费
促销
服务
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  • 包邮
  • 增值税票
数量
-+
产品名称:
4004-05-1
1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine
1,2-二油酰-sn-甘油-3-磷酰乙醇胺
1,2-Di(9Z-octadecenoyl)-sn-glycero-3-phosphoethanolamine
2-氨乙基 (R)-2,3-二(2-油酰氧)丙基磷酸氢酯
产品介绍:

基本信息

分子式C41H78NO8P
分子量744.03
熔点200
MDL编码MFCD00057986
Beilstein1718431
存储条件Freezer -20℃

产品描述

1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) 是阳离子脂质体的中性辅助脂质 (helper lipid),与阳离子磷脂结合,提高裸 siRNA 的转染效率。

靶点(IC50 & Targe)

IC50: helper lipid for liposome[1]

体外研究

In this study, each siRNA is encapsulated in LNP (cationic lipid-A: PEG2000-DMPE: DOPE = 47.8: 5.18: 47.1 molar percent)[1].

With the neutral lipid for the LNP is DOPE, LNP exerts knock-down (KD) effecton macrophages and DCs and Liposome-containing DOPE shows fusogenicity[1].

LNP/siRNA significantly suppresses CD45 protein expression at an inhibition rate of 30% on macrophages and DCs but not on monocytes, neutrophils, plasmacytoid DCs, or B cells[1].

LNP has the potential to be an efficient siRNA delivery system not only for murine but also for human macrophages and DCs[1].

安全信息

WGK3

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