基本信息
| 分子式 | C16H15N3O3 |
| 分子量 | 297.31 |
| 存储条件 | Freezer -20℃ |
产品描述
WHI-P180是多种激酶的抑制剂，对RET和KDR的IC50值分别为4.5 nM和66 nM。
靶点（IC50 & Targe）
CDK2
EGFR
体内研究
The elimination half-life of WHI-P180 in CD-1 mice (BALB/ c mice) following i.v., i.p., or p.o. administration is less than 10 min. Systemic clearance of WHI-P180 is 6742 mL/h/kg in CD-1 mice and 8188 mL/h/kg in BALB/c mice. Notably, WHI-P180, when administered in two consecutive nontoxic i.p. bolus doses of 25 mg/kg, inhibited IgE/antigen-induced vascular hyperpermeability in a well-characterized murine model of passive cutaneous anaphylaxis[2].
参考文献
[1] Rebecca Newton, et al. Eur J Med Chem. 2016, 112: 20-32.
[2] Newton R, et al. Eur J Med Chem. 2016, 112:20-32.
百灵威科技
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