重组新冠RBD单克隆抗体

产品编号

MAV101

产品名称

Recombinant Human anti-COVID-19/SARS-CoV-2 RBD Monoclonal Antibody

抗体亚型

IgG1

规格与价格

100ul/￥3,500; 500ul/￥9,000; 1000ul/￥16,000

克隆号

1G6

产品别名

SARS-CoV-2 RBD antibody, 2019-nCoV, Coronavirus

规格

100ul, 500ul

物种

COVID-19

宿主

Human

产品应用

ELISA, Colloidal Gold, POCT, Neutralizaiton , Standard Positive Control

内毒素水平

<0.1EU/ug determided by LAL method.

缓冲体系

0.01M PBS, pH 7.4

免疫原

Native virus

产品背景

A novel severe acute respiratory syndrome (SARS)-like coronavirus (SARS-CoV-2) recently emerged and is rapidly spreading in humans, causing COVID-19. A key to tackling this pandemic is to understand the receptor recognition mechanism of the virus, which regulates its infectivity, pathogenesis and host range. SARS-CoV-2 and SARS-CoV recognize the same receptor—angiotensin-converting enzyme 2 (ACE2)—in humans. Researchers determined the crystal structure of the receptor-binding domain (RBD) of the spike protein of SARS-CoV-2 (engineered to facilitate crystallization) in complex with ACE2. In comparison with the SARS-CoV RBD, an ACE2-binding ridge in SARS-CoV-2 RBD has a more compact conformation; moreover, several residue changes in the SARS-CoV-2 RBD stabilize two virus-binding hotspots at the RBD–ACE2 interface. These structural features of SARS-CoV-2 RBD increase its ACE2-binding affinity. Additionally, we show that RaTG13, a bat coronavirus that is closely related to SARS-CoV-2, also uses human ACE2 as its receptor.

保存条件

This product can be stored at 2℃-8℃ for one month. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Avoid repeated freeze-thaw cycles.

备注

This product is used for research use only. Not for human or diagnostic use.