产品介绍 基因名： NLRP11 产品别名： CLR19.6； NALP11； NOD17； PAN10； PYPAF6； PYPAF7； NLRP11； NLR family pyrin domain containing 11； NLR family pyrin domain containing 11； NACHT, LRR and PYD domains-containing protein 11； NACHT, leucine rich repeat and PYD containing 11； PAAD- and NACHT-containing protein 10B； PAAD-and NACHT domain-containing protein 10； PYRIN-containing APAF1-like protein 6； nucleotide-binding oligomerization domain protein 17； nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11； NLRP11蛋白； 背景信息： NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008] 标签：His-tag |
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