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蛋白质/抗原/多肽 >> 重组蛋白
重组脱氧胞苷脱氨酶蛋白
重组脱氧胞苷脱氨酶蛋白图片
交货期: 1周
索取资料及报价
交货期:1周
产品别名:Recombinant APOBEC3F
Recombinant apolipoprotein B mRNA editing enzyme catalytic subunit 3F protein
产品介绍
基因名:

APOBEC3F


产品别名:

A3F; ARP8; BK150C2.4.MRNA; KA6; APOBEC3F; apolipoprotein B mRNA editing enzyme catalytic subunit 3F; apolipoprotein B mRNA editing enzyme catalytic subunit 3F; DNA dC->dU-editing enzyme APOBEC-3F; apolipoprotein B editing enzyme catalytic polypeptide-like 3F; apolipoprotein B mRNA editing enzyme cytidine deaminase; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F; induced upon T-cell activation; 脱氧胞苷脱氨酶蛋白;


背景信息:
APOBEC3G is a member of a family of enzymes that have potent DNA mutator activity. APOBEC3G deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G provides a mechanism for innate immunity to retroviruses and also likely contributes to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G resistance to HIV through impaired translation of APOBEC3G mRNA and accel-erated posttranslational degradation of APOBEC3G by the 26S proteasome. Inter-estingly, HIV-1 Vif cannot form a complex with APOBEC3G of mouse origin as it does with the human protein, and thus mouse APOBEC3G functions as a potent inhibitor of wild type HIV-1 replication, where human APOBEC3G is only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G activity or a method of blocking its interaction with Vif may provide a method for therapeutic intervention. CEM15 is a 429 amino acid mouse protein that is thought to function as an ortholog of human APOBEC3G.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。

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