蛋白质/抗原/多肽 >> 重组蛋白
重组转运蛋白DISP2
产品介绍 基因名: DISP2 产品别名: C15orf36; DISPB; HsT16908; LINC00594; DISP2; dispatched RND transporter family member 2; dispatched RND transporter family member 2; protein dispatched homolog 2; dispatched B; long intergenic non-protein coding RNA 594; 转运蛋白DISP2; 背景信息: DISP2 is the second of three known homologs of the D.melanogaster protein Dispatched. It is a multitransmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants. At least two isoforms of DISP2 are known to exist. 标签:His-tag |
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