蛋白质/抗原/多肽 >> 重组蛋白
重组IQCG蛋白
产品介绍 基因名: Iqcg 产品别名: 2400003L07Rik; G1-374-12; esgd12d; repro1; stubby12d; Iqcg; IQ motif containing G; IQ motif containing G; dynein regulatory complex protein 9; IQ domain-containing protein G; IQCG蛋白; 背景信息: IQCG is a 443 amino acid protein containing one IQ domain. Widely distributed in nature, the IQ domain forms an amphiphilic seven-turn α-helix capable of binding calmodulin in a Ca2+-independent manner. The level of intracellular calcium is tightly regulated in all eukaryotic cells. A modest increase in this level can result in a myriad of physiological responses, most of which are mediated by calmodulin (CaM), the universal calcium sensor. In acute T-lymphoid/myeloid leukemia, IQCG forms a complex with Nup98, an O-linked glycoprotein and a component of the nuclear pore complex. NUP98-IQCG complex bind co-activators and/or co-repressors, which suggest a role in transcriptional regulation.Nup98-IQCG complex inhibits 32Dcl3 cell apoptosis induced by Arabinofuranosylcytosine (Ara-C) and partially blocks granulocyte differentiation induced by G-CSF. IQCG exists as two isoforms due to alternatively splicing events. 标签:His-tag |
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