产品介绍 基因名： Marchf7 产品别名： Axo； Axot； Gtrgeo17； March7； Marchf7； membrane associated ring-CH-type finger 7； membrane associated ring-CH-type finger 7； E3 ubiquitin-protein ligase MARCHF7； E3 ubiquitin-protein ligase MARCH7； MARCH-VII； RING-type E3 ubiquitin transferase MARCH7； RING-type E3 ubiquitin transferase MARCHF7； axotrophin； gene trap ROSA b-geo 17； membrane-associated RING finger protein 7； membrane-associated RING-CH protein VII； membrane-associated ring finger (C3HC4) 7； 膜相关环指蛋白7； 背景信息： Axotrophin is a stem cell gene that encodes a protein which is involved in T lymphocyte regulation (especially in regulating the proliferation) and leukemia inhibitory factor (LIF) release. LIF is a neuropoietic cytokine that is important for stem cell regulation and thymocyte stimulation. Both Axotrophin and LIF are linked to transplantation intolerance. Axotrophin is also involved in corpus callosum differentiation and may play a role in glial cell line-derived neurotrophic factor (GDNF)-dependent sensory neuron survival in the substantia gelatinosa of the adult spinal cord. Axotrophin is primarily expressed in the hippocampus, cortex, purkinje and granule cells of the cerebellum. 标签：His-tag |
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