产品介绍 基因名： Coq3 产品别名： Coq3； coenzyme Q3 methyltransferase； coenzyme Q3 methyltransferase； ubiquinone biosynthesis O-methyltransferase, mitochondrial； 2-polyprenyl-6-hydroxyphenol methylase； 2-polyprenyl-6-hydroxyphenyl methylase； 3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase； 3-demethylubiquinol 3-O-methyltransferase； 3-demethylubiquinone-9 3-methyltransferase； DHHB methyltransferase； DHHB-MT； DHHB-MTase； coenzyme Q (ubiquinone)； coenzyme Q3 homolog, methyltransferase； dihydroxyhexaprenylbenzoate methyltransferase； hexaprenyldihydroxybenzoate methyltransferase, mitochondrial； polyprenyldihydroxybenzoate methyltransferase； 线粒体COQ3； 背景信息： Ubiquinone, also known as coenzyme Q, or Q, is a critical component of the electron transport pathways of both eukaryotes and prokaryotes (Jonassen and Clarke, 2000 [PubMed 10777520]). This lipid consists of a hydrophobic isoprenoid tail and a quinone head group. The tail varies in length depending on the organism, but its purpose is to anchor coenzyme Q to the membrane. The quinone head group is responsible for the activity of coenzyme Q in the respiratory chain. The S. cerevisiae COQ3 gene encodes an O-methyltransferase required for 2 steps in the biosynthetic pathway of coenzyme Q. This enzyme methylates an early coenzyme Q intermediate, 3,4-dihydroxy-5-polyprenylbenzoic acid, as well as the final intermediate in the pathway, converting demethyl-ubiquinone to coenzyme Q. The COQ3 gene product is also capable of methylating the distinct prokaryotic early intermediate 2-hydroxy-6-polyprenyl phenol.[supplied by OMIM, Mar 2008] 标签：His-tag |
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