蛋白质/抗原/多肽 >> 重组蛋白
重组活化T细胞核因子胞浆2蛋白
产品介绍 基因名: Nfatc2ip 产品别名: D7Ertd304e; NIP45; Nfatc2ip; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein; nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein; NFATC2-interacting protein; 45 kDa NF-AT-interacting protein; 45 kDa NFAT-interacting protein; nuclear factor of activated T-cells, cytoplasmic 2-interacting protein; 活化T细胞核因子胞浆2; 背景信息: NFATc2IP is a 419 amino acid protein that localizes to both the nucleus and the cytoplasm and contains one ubiquitin-like domain. Interacting with NFATc2, TRAF1 and TRAF2, NFATc2IP plays a role in the inducible expression of cytokines in T-cells, specifically by enhancing NFATc2-induced interleukin (IL) production. NFATc2IP exists as three alternatively spliced isoforms and is subject to post-translational methylation; an event which augments NFATc2IP-regulated cytokine production. The gene encoding NFATc2IP maps to human chromosome 16, which encodes over 900 genes and comprises nearly 3% of the human genome. The GAN gene is located on chromosome 16 and, with mutation, may lead to giant axonal neuropathy, a nervous system disorder characterized by increasing malfunction with growth. The rare disorder Rubinstein-Taybi syndrome is also associated with chromosome 16, as is Crohn's disease, which is a gastrointestinal inflammatory condition. 标签:His-tag |
相关产品
|