产品介绍 基因名： MICAL2 产品别名： Ebitein1； MICAL-2； MICAL2PV1； MICAL2PV2； MICALCL； mical-cL； MICAL2； microtubule associated monooxygenase, calponin and LIM domain containing 2； microtubule associated monooxygenase, calponin and LIM domain containing 2； [F-actin]-monooxygenase MICAL2； ERK2-binding testicular protein 1； MICAL C-terminal like； MICAL C-terminal-like protein； [F-actin]-methionine sulfoxide oxidase MICAL2； ebitein-1； flavoprotein oxidoreductase MICAL2； microtubule associated monoxygenase, calponin and LIM domain containing 2； molecule interacting with CasL protein 2； protein-methionine sulfoxide oxidase MICAL2； ERK2结合睾丸蛋白1； 含微管关联单氧化酶调宁蛋白LIM域蛋白2(MICAL2)； 黄素蛋白氧化还原酶MICAL2； 背景信息： MICALCL is a 695 amino acid cytoplasmic protein that belongs to the ebitein family and interacts with ERK2 during spermatozoa development. MICALCL contains a polymorphic poly-proline region and is encoded by a gene that maps to human chromosome 11p15.3. Chromosome 11 comprises approximately 4% of human genomic DNA and is considered a gene and disease association dense chromosome. The chromosome 11 encoded Atm gene is important for regulation of cell cycle arrest and apoptosis following double strand DNA breaks. Atm mutation leads to the disorder known as ataxia-telangiectasia. The blood disorders Sickle cell anemia and thalassemia are caused by HBB gene mutations, while Wilms' tumors, WAGR syndrome and Denys-Drash syndrome are associated with mutations of the WT1 gene. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11-encoded genes. 标签：His-tag |
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