蛋白质/抗原/多肽 >> 重组蛋白
重组甘露糖苷酶α胞浆蛋白
产品介绍 基因名: MAN2C1 产品别名: CDDG2; MAN6A8; MANA; MANA1; MAN2C1; mannosidase alpha class 2C member 1; mannosidase alpha class 2C member 1; alpha-mannosidase 2C1; alpha mannosidase 6A8B; alpha-D-mannoside mannohydrolase; mannosidase, alpha 6A8; mannosidase, alpha A, cytoplasmic; testicular tissue protein Li 115; 甘露糖苷酶α胞浆; 背景信息: Misfolded glycoproteins are deglycosylated by the peptide N-glycanase during the degradation process. Free oligosaccharides released by N-glycanase are catabolized by cytosolic MAN2C1, also designated alpha-mannosidase 2C1. MAN2C1, a member of the glycosyl hydrolase 38 family, can cleave alpha 1,2-linked, alpha 1,3-linked and alpha 1,6-linked mannose residues and is stimulated by cobalt. The furanose analogs, swainsonine (SW) and 1,4-dideoxy-1,4-imino-d-mannitol (DIM), are known inhibitors of MAN2C1. The inhibition of MAN2C1 can enhance the adhesion of Jurkat T cells, showing a cytoskeletal rearrangement of the cells. 标签:His-tag |
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