蛋白质/抗原/多肽 >> 重组蛋白
重组唐氏综合征细胞粘附分子蛋白
产品介绍 基因名: DSCAM 产品别名: CHD2; CHD2-42; CHD2-52; DSCAM; DS cell adhesion molecule; DS cell adhesion molecule; Down syndrome cell adhesion molecule; 唐氏综合征细胞粘附分子; 背景信息: DSCAM is a cell adhesion molecule belonging to the immunoglobulin superfamily. It is predominantly expressed in brain and contains six Fibronectin type-III domains and ten Ig-like C2-type domains. In mice, DSCAM is responsible for regulating isoneuronal self-avoidance, the tendency for sister arbors to avoid crossing each other and to spread out proportionately over an area. Isoneuronal self-avoidance is important for proper terminal branching (arborization). In some cell types, DSCAM also mediates heteroneuronal self-avoidance, which is important for the regular spacing of cell bodies and the prevention of hyperfasciculation. In humans, two DSCAM isoforms exist due to alternative splicing. The long isoform (also known as CHD2-42) is a single pass type I membrane protein, while the short isoform (CHD2-52), which lacks the C-terminal transmembrane containing region (amino acids 1572-2012), is secreted. 标签:His-tag |
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