UPF3A抗体

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UPF3A抗体


交货期:	1周
产品别名:	Anti-UPF3A Anti-UPF3A regulator of nonsense mediated mRNA decay Antibody

产品介绍

靶标：

UPF3A

产品别名：

HUPF3A； RENT3A； UPF3； UPF3A； UPF3A regulator of nonsense mediated mRNA decay； UPF3A regulator of nonsense mediated mRNA decay； regulator of nonsense transcripts 3A； UPF3 regulator of nonsense transcripts homolog A； hUpf3； nonsense mRNA reducing factor 3A； up-frameshift suppressor 3 homolog A；

背景信息：

This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. The encoded protein is one of two functional homologs to yeast Upf3p. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein binds to the mRNA and remains bound after nuclear export, acting as a nucleocytoplasmic shuttling protein. It forms with Y14 a complex that binds specifically 20 nt upstream of exon-exon junctions. This gene is located on the long arm of chromosome 13. Two splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。