MACROD1蛋白抗体

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MACROD1蛋白抗体


交货期:	1周
产品别名:	Anti-MACROD1 Anti-mono-ADP ribosylhydrolase 1 Antibody

产品介绍

靶标：

MACROD1

产品别名：

LRP16； MACROD1； mono-ADP ribosylhydrolase 1； mono-ADP ribosylhydrolase 1； ADP-ribose glycohydrolase MACROD1； MACRO domain containing 1； MACRO domain-containing protein 1； O-acetyl-ADP-ribose deacetylase MACROD1； [Protein ADP-ribosylaspartate] hydrolase MACROD1； [Protein ADP-ribosylglutamate] hydrolase； [Protein ADP-ribosylglutamate] hydrolase MACROD1； MACROD1蛋白；

背景信息：

Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746). Plays a role in estrogen signaling (PubMed:17893710, PubMed:17914104, PubMed:19403568). Binds to androgen receptor (AR) and amplifies the transactivation function of AR in response to androgen (PubMed:19022849). May play an important role in carcinogenesis and/or progression of hormone-dependent cancers by feed-forward mechanism that activates ESR1 transactivation (PubMed:17893710, PubMed:17914104). Could be an ESR1 coactivator, providing a positive feedback regulatory loop for ESR1 signal transduction (PubMed:17914104). Could be involved in invasive growth by down-regulating CDH1 in endometrial cancer cells (PubMed:17893710). Enhances ESR1-mediated transcription activity (PubMed:17914104).

宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。