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SMPDL3A抗体
产品介绍 靶标: SMPDL3A 产品别名: ASM3A; ASML3a; yR36GH4.1; SMPDL3A; sphingomyelin phosphodiesterase acid like 3A; sphingomyelin phosphodiesterase acid like 3A; acid sphingomyelinase-like phosphodiesterase 3a; 0610010C24Rik; ASM-like phosphodiesterase 3a; 背景信息: SMPDL3A gene is a novel liver X receptor (LXR) -regulated gene, with an LXR response element within its promoter. The induction of SMPDL3A is LXR-dependent and is restricted to human blood cells with no induction observed in mouse cellular systems. LXR α and LXRβ function as physiological sensors of cholesterol metabolites (oxysterols), regulating key genes involved in cholesterol and lipid metabolism. LXRs have been extensively studied in both human and rodent cell systems, revealing their potential therapeutic value in the contexts of atherosclerosis and inflammatory diseases. The LXR genome landscape has been investigated in murine macrophages but not in human THP-1 cells, which represent one of the frequently used monocyte/macrophage cell systems to study immune responses. 宿主:Rbt |
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