DUSP8抗体
产品名称 Anti-DUSP8 Anti-dual specificity phosphatase 8 Antibody 产品介绍
靶标: DUSP8 产品别名: C11orf81; HB5; HVH-5; HVH8; DUSP8; dual specificity phosphatase 8; dual specificity phosphatase 8; dual specificity protein phosphatase 8; H1 phosphatase, vaccinia virus homolog; dual specificity protein phosphatase hVH-5; serine/threonine specific protein phosphatase; 背景信息: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates SAPK/JNK and p38, is expressed predominantly in the adult brain, heart, and skeletal muscle, is localized in the cytoplasm, and is induced by nerve growth factor and insulin. An intronless pseudogene for DUSP8 is present on chromosome 10q11.2. 宿主:Rbt 用户评论 产品评分 目前评分共0人 产品质量
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