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CAS: 637-07-0
分子式: C12H15ClO3
分子量: 242.71
中文名称: 
桂利嗪
氯贝丁酯
冠心平
心血安
祛脂乙酯
降脂乙酯
安妥明
氯贝特
氯苯丁酯
α-对氯苯氧基-α-甲基丙酸乙酯
α-对氯苯氧基-异丁酸乙酯
英文名称: 
2-(p-chlorophenoxy)-2-methyl-propionic aci ethyl ester
2-(4-chlorophenoxy)-2-methylpropanoic acid ethyl ester
2-(p-chlorophenoxy)-2-methylpropionic acid ethyl ester
(p-chlorophenoxy)dimethyl-acetic aci ethyl ester
alpha-(p-chlorophenoxy)isobutyric acid, ethyl ester
alpha-p-chlorophenoxyisobutyryl ethyl ester
amotril
amotril s
angiokapsul
anparton
antilipid
antilipide
apolan
arterioflexin
artevil
ateculon
ateriosan
athebrate
atheromide
atheropront
athranid-wirkstoff
atrolen
atromid
atromid s
atromida
atromidin
atrovis
ay 61123
azionyl
bioscleran
bresit
cartagyl
cinnarizin
citiflus
claripex
claripex cpib
cloberat
clobrat
clobren-sf
clofar
clofibram
clofibrat
clofibrate
clofibrato
clofibrato [spanish]
clofinit
clofipront
cpib
deliva
dura clofibrat
epib
ethyl 2-(4-chlorophenoxy)-2-methylpropionate
ethyl 2-(p-chlorophenoxy)-2-methylpropionate
ethyl 2-(p-chlorophenoxy)isobutyrate
ethyl 2-(para-chlorophenoxy)-2-methylpropionate
ethyl alpha-(4-chlorophenoxy)-alpha-methylpropionate
ethyl alpha-(4-chlorophenoxy)isobutyrate
ethyl alpha-(p-chlorophenoxy)-alpha-methylpropionate
ethyl alpha-(p-chlorophenoxy)isobutyrate
ethyl chlorophenoxyisobutyrate
ethyl clofibrate
ethyl para-chlorophenoxyisobutyrate
ethyl-alpha-p-chlorophenoxy-isobutyrate
fibralem
gerastop
hyclorate
ici 28257
alpha-(p-chlorophenoxy)-isobutyric aci ethyl ester
klofiran
levatrom
lipamid
lipavil
lipavlon
lipide 500
lipidsenker
lipofacton
lipomid
liponorm
liporeduct
liporil
liposid
liprin
liprinal
lobetrin
miscleron
misclerone
negalip
neo-atromid
normalip
normet
normolipol
nsc-79389
oxan 600
persantinat
2-(4-chlorophenoxy)-2-methyl-propanoic aci ethyl ester
2-(4-chlorophenoxy)-2-methyl-propionic aci ethyl ester
recolip
regardin
regelan
regelan n
robigram
scrobin
serotinex
skerolip
sklero-tablinen
sklero-tabuls
skleromex
skleromexe
ticlobran
vincamin compositum
xyduril
yoclo
chlorophenoxyisobutyricacidethylester
Ethyl 2-(p-chlorophenoxy)-2-mefhyl-pro-pionate
Ethyl p-chlorophenoxyisobutyrate
Atro-midin
2-(4-Chlorophenoxy)-2-methylpropionic acid ethyl ester
2-(4-Chlorophenoxy)isobutyric Acid Ethyl Ester
Ethyl 2-(4-Chlorophenoxy)isobutyrate
Clofibrinic acid ethyl ester
性质描述: 该品为无色或黄色透明油状液体,略及异臭。不溶于水,可溶于乙醇、丙酮、氯仿、乙醚。沸点148-150℃(2.67kPa)。
生产方法: 按照采用的原料划分,该品合格路线主要有两条,一是以对氨基苯酚为原料经重氮化、置换制得对氯苯酚,再经缩合、水解,酸化生成对氯苯氧异丁酸,最后酯化得安妥明。这条路线步骤较长,所用原料对氨基酚不稳定,但比较成熟。二是以苯酚为原料,经缩合生成苯氧异丁酸,再于乙醇中通氯,进行氯化及酯化反应生成安妥明。
用途: 降血脂药。能抑制胆固醇和甘油三酯的合成,增加固醇类的排泄,降低血中ULDL的含量,临床证明该品降甘油三酯作用较降胆醇作用明显,作用强时甘油三酯可降低30-40%,胆固醇可降低15-20%,适用于Ⅲ、Ⅳ、Ⅴ型高血酯症,对Ⅲ型尤佳,对部分Ⅱb型也有效,此外,该品能降低血浆纤维蛋白元的含量和血小板的粘性,因而,有利于防止血栓的形成,减少心肌梗塞的发病率,用于高酯血症及动脉硬化症等。服用该品个别病人有恶心、呕吐、食欲不振、腹胀、腹泻等症状。为了减少胃肠道反应,开始时宜采用小剂量,以后逐渐增量,但在治疗的第一个月应达到规定剂量。停药时最好也采用递减方法。肝肾功能不全者慎用。孕妇忌用。毒性:口服LD50小鼠1.28g/kg;大鼠1.65g/kg。
637-07-0 供应商:
公司名称:广州伟伯科技有限公司
业务QQ:2483205017
联系电话:020-36393398
联系传真:020-36393398
产品详情:637-07-0
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