CAS 60-79-7; 麦角新碱; 9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergo line-8beta(S)-carboxami

CAS:

60-79-7

分子式:

C19H23N3O2

分子量:

325.39

中文名称:

麦角新碱

麦角袂春

爱谷米特邻碱

爱各米特令碱

英文名称:

n-(1-(hydroxymethyl)ethyl)-d-lysergomide

ergostetrine

ergotocine

ermetrine

l-lysergic-l(beta-hydroxyisopropylamide)

n-((S)-2-hydroxy-1-methylethyl)-lysergamid

lysergic acid propanolamide

margonovine

n-(1-(hydroxymethyl)ethyl)-d-lysergamide

ergonovine

n-(1-hydroxymethyl)ethyl)-d-lysergomide

n-(alpha-(hydroxymethyl)ethyl)-d-lysergamide

n-(alpha-(hydroxymethyl)ethyl)-d-lysergomide

neofemergen

secacornin

secometrin

9,10-Didehydro-N-(2-hydroxy-1-methylethyl)-6-methylergdine-8-carboxamide

N-[-(Hydroxyme-thyl)ethyl]-D-lysergamide

ergobasine

9,10-didehydro-n-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-ca rbox

9,10-dihydro-n-(alpha-(hydroxymethyl)ethyl)-6-methylergoline-8-beta-carboxamide

basergin

d-lysergic acid 1-hydroxymethylethylamide

d-lysergic acid l-2-propanolamide

d-lysergic acid-l,2-propanolamide

d-lysergic acid-l-propanolamide

ergoatetrine

9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergo line-8beta(S)-carboxami

ergoklinine

9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methyl-ergoline-8-carboxamid

(8-beta(S))-

9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methyl-ergoline-8-carboxamid (

ergoline-8beta-carboxamide, 9,10-didehydro-n-((S)-2-hydroxy-1-methylethyl)-6-me

ergometrin

ergometrine

性质描述:

白色细结晶。熔点162-163℃。易溶于低级醇类、乙酸乙酯和丙酮，微溶于氯仿。在水中的溶解度比麦角中其他生物碱为高。

生产方法:

用发酵法生产。

用途:

该品为子宫兴奋药。一般制成麦角新碱顺丁烯二酸盐（马来酸麦角新碱）。麦角制剂主要用于预防和治疗产后子宫出血及治疗子宫复原不佳等。但由于麦角制剂使子宫底及子宫颈平滑肌同时呈现收缩，不利于胎儿娩出，所以不作催产和引产用。马来酸麦角新碱对鼠静脉注射LD50为8.26mg/kg。