CAS 514-65-8; 比哌立登; a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol

CAS:

514-65-8

分子式:

C21H29NO

分子量:

311.46

中文名称:

比哌立登

3-哌啶基-1-苯基-双环庚烯基-1-丙醇

英文名称:

a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol

α-bicyclo[2.2.1]hept-5-en-2yl-α-phenyl-1-piperidinepropanol

alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropano

1-bicycloheptenyl-1-phenyl-3-piperidino-propanol-1

alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropano

3-piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1)

3-piperidino-1-phenyl-1-bicycloheptenyl-1-propanol

alpha-phenyl-alpha-(2-piperidinoethyl)-5-norbornene-2-methano

akineton

akinophyl

alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol

beperiden

biperiden

kl 373

-Bicyclo[2,2,1]hept-5-en-2yl-phenyl-1-piperidinepropanol

-5-Norbornen-2-yl-phenyl-1-piperidine propanol

3-Piperidino-1-phenyl-1-bicyclo-

性质描述:

该品为结晶体。熔点112-116℃（101℃）。不易溶于水，微溶于乙醇，易溶于甲醇。该品的盐酸盐（C21H29NO·HCI）又称安克痉（Akineton，Akinophyl)，为白色结晶。约275℃分解，也有报道其熔点为238℃。

生产方法:

以环戊二烯为原料，先与氯乙烯合成氯代双环庚烯，再与镁和乙醚反应，得双环庚烯镁化氯，最后与β-哌啶苯丙酮缩合制得比哌立登。β-哌啶苯丙酮的制备：以苯乙酮为原料与哌啶盐酸盐、甲醛、二甲胺经曼氏反应得到。

用途:

该品为抗震颤麻痹药、解痉药。小鼠口服LD50为545mg/kg，静脉注射为56mg/kg。